Royal Air Force Typhoon fighter aircraft have operated alongside French aircraft in a coordinated attack targeting an underground arms cache in Syria employed by the IS group, as stated by the UK's MoD.
The location, located using reconnaissance, was thought to be containing munitions and bombs, the announcement noted, and was situated in hills just to the north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes employed Paveway IV guided bombs to hit a series of approach shafts providing entry to the site... initial indications suggest the strike was effective," the ministry announced.
There was no indication of any civilian casualties in the attack conducted Saturday night and each participating jet made a safe return, the MoD added.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - also known as ISIS - enforced militant control over significant areas in Syria and Iraq until 2019.
"This action underscores the UK's leading role, and resolve to stand shoulder to shoulder with our allies, to eliminate any resurgence of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary the minister remarked.
British military aircraft have carried out patrols over Syrian airspace to "prevent any efforts to regroup" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I must thank the personnel of the UK armed forces involved in this mission for their professionalism and their courage," the Defence Secretary commented. "They were among numerous British troops stationed over the festive period. This mission, to remove dangerous terrorists who threaten our security, highlights how British military are always on standby, throughout the year, keeping Britain secure within its borders and strong abroad."
During December, the US military carried out what it termed a "large-scale strike" targeting Islamic State objectives in the country, after an ambush killed two US troops and a civilian interpreter in the Palmyra area.
The United Nations reports Islamic State still has an estimated 5,000 to 7,000 fighters in Syria and Iraq.